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Article

Incomplete Re‐Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β‐Cell Dedifferentiation

28 Nov 2016

Abstract excerpt

There is increasing evidence to suggest that type 2 diabetes mellitus (T2D), a pandemic metabolic disease, may be caused by β-cell dedifferentiation (βCD). However, there is currently no universal definition of βCD, and the underlying mechanism is poorly understood. We hypothesise that a high-glucose in vitro environment mimics hyperglycaemia in vivo and that β cells grown in this milieu over a long period will...

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PMID: 27891681
DOI: 10.1111/jne.12450

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