QPOLE: A Quick, Simple, and Cheap Alternative for POLE Sequencing in Endometrial Cancer by Multiplex Genotyping Quantitative Polymerase Chain Reaction.

doi:10.1200/GO.22.00384

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Article

QPOLE: A Quick, Simple, and Cheap Alternative for POLE Sequencing in Endometrial Cancer by Multiplex Genotyping Quantitative Polymerase Chain Reaction.

JCO global oncology - 1 May 2023

Van den Heerik Anne Sophie V M, Ter Haar Natalja T, Vermij Lisa, Jobsen Jan J, Brinkhuis Mariel, Roothaan Suzan M, Leon-Castillo Alicia, Ortoft Gitte, Hogdall Estrid, Hogdall Claus, Van Wezel Tom, Lutgens Ludy C H W, Haverkort Marie A D, Khattra Jas, McAlpine Jessica N, Creutzberg Carien L, Smit Vincent T H B M, Gilks C Blake, Horeweg Nanda, Bosse Tjalling

Abstract excerpt

PURPOSE: Detection of 11 pathogenic variants in the POLE gene in endometrial cancer (EC) is critically important to identify women with a good prognosis and reduce overtreatment. Currently, POLE status is determined by DNA sequencing, which can be expensive, relatively time-consuming, and unavailable in hospitals without specialized equipment and personnel. This may hamper the implementation of POLE-testing in...

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Identifiers

PMID: 37229628
DOI: 10.1200/GO.22.00384
PMCID: PMC10497260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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