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Article

Clinical evaluation of a droplet digital PCR assay for detecting POLE mutations and molecular classification of endometrial cancer.

Journal of gynecologic oncology - 1 Mar 2022

Kim Gilhyang, Lee Song Kook, Suh Dong Hoon, Kim Kidong, No Jae Hong, Kim Yong Beom, Kim Hyojin

Abstract excerpt

OBJECTIVE: We evaluated droplet digital polymerase chain reaction (ddPCR) method for detecting POLE mutations in endometrial cancer (EC) and guiding its molecular classification. METHODS: We reviewed 240 EC specimens from our hospital database. A ddPCR assay was used to identify POLE mutations at 5 known hotspots (P286R, S297F, V411L, A456P, and S459F). Expressions of p53 and mismatch repair proteins were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34910396
DOI: 10.3802/jgo.2022.33.e15
PMCID: PMC8899877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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