Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fast and reliable Sanger POLE sequencing protocol in FFPE tissues of endometrial cancer.

Pathology, research and practice - 1 Feb 2023

Laczmanska Izabela, Michalowska Dagmara, Jedryka Marcin, Blomka Dorota, Semeniuk Mariola, Czykalko Ewelina, Abrahamowska Mariola, Mlynarczykowska Paulina, Chrusciel Agnieszka, Pawlak Ireneusz, Maciejczyk Adam

Abstract excerpt

BACKGROUND: The new classification of endometrial carcinoma (EC) requires molecular interpretation of somatic polymerase epsilon (POLE) exonuclease domain mutations. The identification of pathogenic mutations within the POLE gene defines the important subtype of ultramutated tumours ("POLE-ultramutated") with specified prognostic and predictive utility. POLE somatic mutations are present in 7-12% of ECs, usually...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endometrial Neoplasms
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mutation

Share to Poly-ADP-Ribose Binding Proteins

Share to Prognosis

Source

Identifiers

PMID: 36738508
DOI: 10.1016/j.prp.2023.154315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fast and reliable Sanger POLE sequencing protocol in FFPE tissues of endometrial cancer.PMID 36738508Read ↗

A Multiplex SNaPshot Assay is a Rapid and Cost-Effective Method for Detecting POLE Exonuclease Domain Mutations in Endometrial Carcinoma.Semantic proximity Read ↗

Interpretation of somatic POLE mutations in endometrial carcinoma.Semantic proximity Read ↗

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.Semantic proximity Read ↗

QPOLE: A Quick, Simple, and Cheap Alternative for POLE Sequencing in Endometrial Cancer by Multiplex Genotyping Quantitative Polymerase Chain Reaction.Semantic proximity Read ↗

POLE mutations in endometrial carcinoma: Clinical and genomic landscape from a large prospective single‐center cohortSemantic proximity Read ↗

POLE exonuclease domain mutations in endometrial carcinoma: a case report.Semantic proximity Read ↗

The clinicopathology and survival characteristics of patients with POLE proofreading mutations in endometrial carcinoma: A systematic review and meta-analysis.Semantic proximity Read ↗

A novel somatic mutation in POLE exonuclease domain associated with ultra-mutational signature and MMR deficiency in endometrial cancer: a case report.Semantic proximity Read ↗

Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.Semantic proximity Read ↗

Pathogenic POLE-Mutated Endometrial Carcinomas With a Nonultramutated Genome.Semantic proximity Read ↗

Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.Semantic proximity Read ↗

Clinicopathologic and protein markers distinguishing the "polymerase epsilon exonuclease" from the "copy number low" subtype of endometrial cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.