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Article

IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.

The Journal of investigative dermatology - 1 Nov 2023

Ke Yao, Li Ben-Zheng, Nguyen Khoa, Wang Donna, Wang Suyan, Young Christian D, Wang Xiao-Jing

Abstract excerpt

Long-term management of inflammatory skin diseases is challenging because of side effects from repeated use of systemic treatments or topical corticosteroids. This study sought to identify the mechanisms and developmental therapeutics for these diseases using genetic models and pharmacological approaches. We found that mice overexpressing SMAD7 in keratinocytes but not mice overexpressing the N-terminal domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 37211203
DOI: 10.1016/j.jid.2023.04.029
PMCID: PMC11127768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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