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Article

STAT1 activation represses IL-22 gene expression and psoriasis pathogenesis.

Biochemical and biophysical research communications - 22 Jun 2018

Bai Li, Fang Huihui, Xia Sisi, Zhang Ruochan, Li Liwu, Ochando Jordi, Xu Jiangnan, Ding Yaozhong

Abstract excerpt

IL-22 plays an important role in tissue repair and inflammatory responses, and is implicated in the pathogenesis of psoriasis, ulcerative colitis, as well as liver and pancreas damage. The molecular mechanisms of its regulation have been actively studied. Here, we show that the differential regulation of IL-22 expression in CD4+ T cells by IL-6 and IL-27 was detected rapidly after stimulation. Chromatin...

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Source

Identifiers

PMID: 29750958
DOI: 10.1016/j.bbrc.2018.05.042

Genes

STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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