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From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment

23 Jun 2021

Abstract excerpt

The paradigm of psoriasis as a Th17-driven disease has evolved in the last years towards a much deeper knowledge of the complex pathways, mechanisms, cells, and messengers involved, highlighting the crucial role played by the IL-17 family of cytokines. All IL-17 isoforms signal through IL-17R. Five subunits of IL-17R have been described to date, which couple to form a homo- or hetero-receptor complex....

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PMID: 34201664
DOI: 10.3390/ijms22136740

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