Article

Disease context dictates the cellular targets of IL-17 in inflammatory skin disease

2026-03-25

Abstract excerpt

Therapeutic blockade of IL-17 and TNF can effectively treat inflammatory skin diseases such as hidradenitis suppurativa and psoriasis, yet the relative importance of the different cell types that respond to IL-17 and TNF remains unresolved. Keratinocytes are viewed as the dominant effector cells, whereas fibroblasts have recently emerged as important contributors. In mice, topical imiquimod induces IL-17- and TNF-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b6155e1-666b-52d6-ad71-e509cae45a77
DOI: 10.64898/2026.03.23.713409

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease context dictates the cellular targets of IL-17 in inflammatory skin diseaseDOI 10.64898/2026.03.23.713409Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytesSemantic proximity Read

Transcriptomic Analysis of Hidradenitis Suppurativa: A Unique Molecular Signature with Broad Immune ActivationSemantic proximity Read

Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 functionSemantic proximity Read

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in PsoriasisSemantic proximity Read

Local IL-17 orchestrates skin agingSemantic proximity Read

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory ResponsesSemantic proximity Read

IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory PhenotypeSemantic proximity Read

Skin immune microenvironment in psoriasis: from bench to bedsideSemantic proximity Read

The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory GenesSemantic proximity Read

T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblastsSemantic proximity Read

Th17 cells with regulatory phenotype are the main IL-17F and IL-26 producers in palmoplantar pustulosis.Semantic proximity Read