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Article

Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function

26 Sept 2016

Abstract excerpt

Psoriasis is a chronic inflammatory skin disease with a clear genetic contribution, characterized by keratinocyte proliferation and immune cell infiltration. Various closely interacting cell types, including innate immune cells, T cells, and keratinocytes, are known to contribute to inflammation. Innate immune cells most likely initiate the inflammatory process by secretion of IL-23. IL-23 mediates expansion of T...

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PMID: 27671649
DOI: 10.1073/pnas.1606996113

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