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Article

Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

The Journal of investigative dermatology - 1 Mar 2017

Fritz Yi, Klenotic Philip A, Swindell William R, Yin Zhi Qiang, Groft Sarah G, Zhang Li, Baliwag Jaymie, Camhi Maya I, Diaconu Doina, Young Andrew B, Foster Alexander M, Johnston Andrew, Gudjonsson Johann E, McCormick Thomas S, Ward Nicole L

Abstract excerpt

IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels of tissue and serum IL-6 in patients. In addition, de novo psoriasis onset has been reported after IL-6 blockade in patients with rheumatoid arthritis. To explore mechanisms underlying these clinical observations, we backcrossed an established psoriasiform mouse model (IL-17C+ mice) with IL-6-deficient mice (IL-17C+KO) and examined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27984037
DOI: 10.1016/j.jid.2016.10.021
PMCID: PMC5326585

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