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Article

Unraveling the biological functions of Smad7 with mouse models

1 Dec 2011

Abstract excerpt

Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes. The physiological actions of Smad7 have been extensively investigated by using various mouse models. These studies have pinpointed numerous important in vivo functions of Smad7, including its activity in early embryonic development, fibrosis of...

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PMID: 22204639
DOI: 10.1186/2045-3701-1-44

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