Article
Whole exome sequencing of low grade serous ovarian carcinoma identifies genomic events associated with clinical outcome.
Gynecologic oncology - 1 Jul 2023
Thomson John P, Hollis Robert L, van Baal Juliette, Ilenkovan Narthana, Churchman Michael, van de Vijver Koen, Dijk Frederike, Meynert Alison M, Bartos Clare, Rye Tzyvia, Croy Ian, Diana Patricia, van Gent Mignon, Creedon Helen, Nirsimloo Rachel, Nussey Fiona, Lok Christianne, Herrington C Simon, Gourley Charlie
Abstract excerpt
OBJECTIVES: Low-grade serous ovarian carcinoma (LGSOC) is a distinct, rare, ovarian cancer type characterised by younger patient age and intrinsic chemoresistance. Understanding the molecular landscape is crucial for optimising targeted therapy. METHODS: Genomic data from whole exome sequencing of tumour tissue was analysed in a LGSOC cohort with detailed clinical annotation. RESULTS: 63 cases were analysed and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.