Article
MAPK Pathway Genetic Alterations Are Associated with Prolonged Overall Survival in Low-Grade Serous Ovarian Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Oct 2022
Manning-Geist Beryl, Gordhandas Sushmita, Liu Ying L, Zhou Qin, Iasonos Alexia, Da Cruz Paula Arnaud, Mandelker Diana, Long Roche Kara, Zivanovic Oliver, Maio Anna, Kemel Yelena, Chi Dennis S, O'Cearbhaill Roisin E, Aghajanian Carol, Weigelt Britta, Chui M Herman, Grisham Rachel N
Abstract excerpt
PURPOSE: To characterize the somatic mutational landscape, investigate associations between genetic alterations and clinical outcomes, and determine the prevalence of pathogenic germline mutations in low-grade serous ovarian carcinomas (LGSC). EXPERIMENTAL DESIGN: Patients with LGSC tumors who underwent panel-based sequencing of up to 505 genes were identified. Data on somatic and germline mutations; copy-number...
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