Article

Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome

2020-03-24

Abstract excerpt

Endometrioid ovarian carcinoma (EnOC) is an under-investigated type of ovarian carcinoma. Here, we report the largest genomic study of EnOCs to date, performing whole exome sequencing of 112 cases following rigorous pathological assessment. High frequencies of mutation were detected in CTNNB1 (43%), PIK3CA (43%), ARID1A (36%), PTEN (29%), TP53 (26%) and SOX8 (19%), a novel target of recurrent mutation in EnOC. POL...

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Literature Corpus work: 85e40b9d-e1f7-5f0e-b9a1-59e24dcba68c
DOI: 10.1101/2020.03.19.20038786

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