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Genomic profiling in low grade serous ovarian cancer: Identification of novel markers for disease diagnosis and therapy.

Gynecologic oncology - 1 Nov 2022

ElNaggar Adam, Robins David, Baca Yasmine, Arguello David, Ulm Michael, Arend Rebecca, Mantia-Smaldone Gina, Chu Christina, Winer Ira, Holloway Rob, Krivak Tom, Jones Nathaniel, Galvan-Turner Valerie, Herzog Thomas J, Brown Jubilee

Abstract excerpt

OBJECTIVES: Low grade serous ovarian cancer (LGSOC) differs from high grade serous in terms of pathogenesis, molecular, genetic, and clinical features. Molecular studies have been hampered by small sample sizes, heterogenous histology, and lack of comprehensive testing. We sought to molecularly profile LGSOC in a homogenously tested, histologically confirmed cohort. METHODS: Using hot-spot and whole exome next...

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Cystadenocarcinoma, Serous
Genomics
Hormones
Mutation
Neoplasm Grading

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

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PMID: 36229265
DOI: 10.1016/j.ygyno.2022.09.022

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