Article
Integrating multiple traits for improving polygenic risk prediction in disease and pharmacogenomics GWAS.
Briefings in bioinformatics - 20 Jul 2023
Zhai Song, Guo Bin, Wu Baolin, Mehrotra Devan V, Shen Judong
Abstract excerpt
Polygenic risk score (PRS) has been recently developed for predicting complex traits and drug responses. It remains unknown whether multi-trait PRS (mtPRS) methods, by integrating information from multiple genetically correlated traits, can improve prediction accuracy and power for PRS analysis compared with single-trait PRS (stPRS) methods. In this paper, we first review commonly used mtPRS methods and find that...
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