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Article

mtPGS: Leverage multiple correlated traits for accurate polygenic score construction.

American journal of human genetics - 5 Oct 2023

Xu Chang, Ganesh Santhi K, Zhou Xiang

Abstract excerpt

Accurate polygenic scores (PGSs) facilitate the genetic prediction of complex traits and aid in the development of personalized medicine. Here, we develop a statistical method called multi-trait assisted PGS (mtPGS), which can construct accurate PGSs for a target trait of interest by leveraging multiple traits relevant to the target trait. Specifically, mtPGS borrows SNP effect size similarity information between...

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Identifiers

PMID: 37716346
DOI: 10.1016/j.ajhg.2023.08.016
PMCID: PMC10577082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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