On polygenic risk scores for complex traits prediction.

Abstract excerpt

Polygenic risk scores (PRS) have gained substantial attention for complex traits prediction in genome-wide association studies (GWAS). Motivated by the polygenic model of complex traits, we study the statistical properties of PRS under the high-dimensional but sparsity free setting where the triplet (n,p,m)→(∞,∞,∞)$(n,p,m) \rightarrow (\infty , \infty , \infty )$ with n,p,m$n, p, m$ being the sample size, the...

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