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Article

A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data.

Epigenetics - 1 Dec 2023

Zheng Yuanchao, Lunetta Kathryn L, Liu Chunyu, Smith Alicia K, Sherva Richard, Miller Mark W, Logue Mark W

Abstract excerpt

Differentially methylated regions (DMRs) are genomic regions with methylation patterns across multiple CpG sites that are associated with a phenotype. In this study, we proposed a Principal Component (PC) based DMR analysis method for use with data generated using the Illumina Infinium MethylationEPIC BeadChip (EPIC) array. We obtained methylation residuals by regressing the M-values of CpGs within a region on...

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Identifiers

PMID: 37196182
DOI: 10.1080/15592294.2023.2207959
PMCID: PMC10193914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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