Article

Comethyl: A network-based methylome approach to investigate the multivariate nature of health and disease

2021-07-14

Abstract excerpt

Health outcomes are frequently shaped by difficult to dissect inter-relationships between biological, behavioral, social, and environmental factors. DNA methylation patterns reflect such multi-variate intersections, providing a rich source of novel biomarkers and insight into disease etiologies. Recent advances in whole-genome bisulfite sequencing (WGBS) enable investigation of DNA methylation over all genomic CpG...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 856f6f8a-32d4-5699-aeb2-a8613cb786d2
DOI: 10.1101/2021.07.14.452385

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comethyl: A network-based methylome approach to investigate the multivariate nature of health and diseaseDOI 10.1101/2021.07.14.452385Read

Multi-tissue DNA methylation microarray signature is predictive of gene function.Semantic proximity Read

coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns.Semantic proximity Read

RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord bloodSemantic proximity Read

Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traitsSemantic proximity Read

<i>DMRscaler</i> : A Scale-Aware Method to Identify Regions of Differential DNA Methylation Spanning Basepair to Multi-Megabase FeaturesSemantic proximity Read

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read

A first-generation genome-wide map of correlated DNA methylation demonstrates highly coordinated and tissue-independent clustering across regulatory regionsSemantic proximity Read

The EWAS Catalog: a database of epigenome-wide association studiesSemantic proximity Read

The EWAS Catalog: a database of epigenome-wide association studiesSemantic proximity Read

Integration of public DNA methylation and expression networks via eQTMs improves prediction of functional gene–gene associationsSemantic proximity Read

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)Semantic proximity Read

Epigenomic convergence of genetic and immune risk factors in neurodevelopmental disorder cortexSemantic proximity Read