Article
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches.
Epigenetics & chromatin - 14 Oct 2025
Höffler Kira D, Katrinli Seyma, Halvorsen Matthew W, Stavrum Anne-Kristin, O'Connell Kevin S, Shadrin Alexey, Djurovic Srdjan, Andreassen Ole A, Crowley James J, Haavik Jan, Hagen Kristen, Kvale Gerd, Ressler Kerry, Hansen Bjarne, Soares Jair C, Fries Gabriel R, Smith Alicia K, Le Hellard Stéphanie
Abstract excerpt
BACKGROUND: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genotyping data is not available. However, this method does not remove technical and biological variations, such as sex and age,...
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