Article
Accounting for population stratification in DNA methylation studies.
Genetic epidemiology - 1 Apr 2014
Barfield Richard T, Almli Lynn M, Kilaru Varun, Smith Alicia K, Mercer Kristina B, Duncan Richard, Klengel Torsten, Mehta Divya, Binder Elisabeth B, Epstein Michael P, Ressler Kerry J, Conneely Karen N
Abstract excerpt
DNA methylation is an important epigenetic mechanism that has been linked to complex diseases and is of great interest to researchers as a potential link between genome, environment, and disease. As the scale of DNA methylation association studies approaches that of genome-wide association studies, issues such as population stratification will need to be addressed. It is well-documented that failure to adjust for...
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