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Fine tuning contractility: atrial sarcomere function in health and disease

29 Dec 2023

Abstract excerpt

The molecular mechanisms of sarcomere proteins underlie the contractile function of the heart. Although our understanding of the sarcomere has grown tremendously, the focus has been on ventricular sarcomere isoforms due to the critical role of the ventricle in health and disease. However, atrial-specific or -enriched myofilament protein isoforms, as well as isoforms that become expressed in disease, provide...

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PMID: 38156887
DOI: 10.1152/ajpheart.00252.2023

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