Article
R4496C RyR2 mutation impairs atrial and ventricular contractility.
The Journal of general physiology - 1 Jan 2016
Ferrantini Cecilia, Coppini Raffaele, Scellini Beatrice, Ferrara Claudia, Pioner Josè Manuel, Mazzoni Luca, Priori Silvia, Cerbai Elisabetta, Tesi Chiara, Poggesi Corrado
Abstract excerpt
Ryanodine receptor (RyR2) is the major Ca(2+) channel of the cardiac sarcoplasmic reticulum (SR) and plays a crucial role in the generation of myocardial force. Changes in RyR2 gating properties and resulting increases in its open probability (Po) are associated with Ca(2+) leakage from the SR and arrhythmias; however, the effects of RyR2 dysfunction on myocardial contractility are unknown. Here, we investigated...
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