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Article

Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2023

Lee Chien-Der, Ziv Naomi, Johnson Alexander D

Abstract excerpt

A fundamental question in biology is how a eukaryotic cell type can be stably maintained through many rounds of DNA replication and cell division. In this paper, we investigate this question in a fungal species, Candida albicans, where two different cells types (white and opaque) arise from the same genome. Once formed, each cell type is stable for thousands of generations. Here, we investigate the mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37186823
DOI: 10.1073/pnas.2220568120
PMCID: PMC10214202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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