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Article

The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand.

Life science alliance - 1 Jul 2023

Takada Yoko K, Simon Scott I, Takada Yoshikazu

Abstract excerpt

Recognition of integrins by CD62P has not been reported and this motivated a docking simulation using integrin αvβ3 as a target. We predicted that the C-type lectin domain of CD62P functions as a potential integrin ligand and observed that it specifically bound to soluble β3 and β1 integrins. Known inhibitors of the interaction between CD62P-PSGL-1 did not suppress the binding, whereas the disintegrin domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37184585
DOI: 10.26508/lsa.202201747
PMCID: PMC10130748

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