Article
The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain.
The Journal of biological chemistry - 24 Jan 2014
Podolnikova Nataly P, Yakovlev Sergiy, Yakubenko Valentin P, Wang Xu, Gorkun Oleg V, Ugarova Tatiana P
Abstract excerpt
The currently available antithrombotic agents target the interaction of platelet integrin αIIbβ3 (GPIIb-IIIa) with fibrinogen during platelet aggregation. Platelets also bind fibrin formed early during thrombus growth. It was proposed that inhibition of platelet-fibrin interactions may be a necessary and important property of αIIbβ3 antagonists; however, the mechanisms by which αIIbβ3 binds fibrin are uncertain....
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