Article
Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009
Waldron Travis T, Springer Timothy A
Abstract excerpt
The selectins are cell adhesion proteins that must resist applied forces to mediate leukocyte tethering and rolling along the endothelium and have 2 conformational states. Selectin-ligand bond dissociation increases only modestly with applied force, and exhibits catch bond behavior in a low-force regime where bond lifetimes counterintuitively increase with increasing force. Both allosteric and sliding-rebinding...
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