Article
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.
Molecular cell - 24 Apr 2009
Zhu Jieqing, Luo Bing-Hao, Barth Patrick, Schonbrun Jack, Baker David, Springer Timothy A
Abstract excerpt
Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate association and signaling through transmembrane domains. A chemical and computational method to determine structures of the membrane regions of such receptors on the cell surface is developed here and validated with glycophorin A. An integrin heterodimer structure...
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