Article
Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach.
Current medicinal chemistry. Cardiovascular and hematological agents - 1 Jun 2003
Lu X, Lu D, Scully M F, Kakkar V V
Abstract excerpt
Integrins are a family of heterodimeric class I transmembrane receptors, many of which bind to the RGD sequence in adhesive proteins and mediate the adhesive interactions of a variety of cells. The RGD motif has also been found in snake venom proteins that specifically inhibit integrin binding function and serve as potent integrin antagonists. The majority of these proteins interact with beta1 and beta3...
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