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Article

ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications.

Trends in molecular medicine - 1 Aug 2023

Jin Fukang, Yang Zhiguang, Shao Jingbo, Tao Jianxin, Reißfelder Christoph, Loges Sonja, Zhu Lei, Schölch Sebastian

Abstract excerpt

Mutations in the AT-interacting domain-rich protein 1A (ARID1A) gene, a critical component of the switch/sucrose nonfermentable (SWI/SNF) complex, are frequently found in most human cancers. Approximately 5-10% of lung cancers carry ARID1A mutations. ARID1A loss in lung cancer correlates with clinicopathological features and poor prognosis. Co-mutation of ARID1A and epidermal growth factor receptor (EGFR) results...

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PMID: 37179132
DOI: 10.1016/j.molmed.2023.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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