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Article

Loss of ARID1A expression promotes lung adenocarcinoma metastasis and predicts a poor prognosis.

Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2021

Sun Dantong, Zhu Yan, Zhao Han, Bian Tiantian, Li Tianjun, Liu Kewei, Feng Lizong, Li Hong, Hou Helei

Abstract excerpt

BACKGROUND: ARID1A is an essential subunit of SWI/SNF chromatin remodeling complexes. ARID1A gene mutations and loss of ARID1A expression have been observed in a variety of cancers, and to be correlated with invasion, immune escape and synthetic lethality. As yet, however, the biological effect of ARID1A expression and its role in the prognosis of lung adenocarcinoma (LUAD) patients have remained unclear. In this...

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Identifiers

PMID: 34109546
DOI: 10.1007/s13402-021-00616-x
PMCID: PMC12980766

Genes

ARID1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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