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ARID1A Mutation in Metastatic Breast Cancer: A Potential Therapeutic Target

4 Nov 2021

Abstract excerpt

Distant metastasis is the principal cause of mortality for breast cancer patients. Targeting specific mutations that have been acquired during the evolution process of advanced breast cancer is a potential means of enhancing the clinical efficacy of treatment strategies. In metastatic breast cancer, ARID1A is the most prevalent mutation of the SWI/SNF complex, which regulates DNA repair, recombination, and gene...

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PMID: 34804958
DOI: 10.3389/fonc.2021.759577

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