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Article

ARID1A mutational status in non-small cell lung cancer: from molecular pathology to clinical implications with a focus on the relationships with EGFR.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2025

Di Lecce Claudia, Eccher Serena, Simbolo Michele, Cocomazzi Alessandra, Piredda Maria L, Caliò Anna, Cima Luca, Munari Enrico, Veronese Nicola, Avancini Alice, Zanconati Fabrizio, Milella Michele, Scarpa Aldo, Pilotto Sara, Belluomini Lorenzo, Luchini Claudio

Abstract excerpt

Lung cancer is the most frequently diagnosed malignancy worldwide and remains the leading cause of cancer-related mortality. Non-small-cell lung cancer (NSCLC) is the most prevalent type of lung cancer, with epidermal growth factor receptor (EGFR) gene mutations being among the most frequently reported. ARID1A (AT-Rich Interactive Domain 1A), a key component of the switch/sucrose non-fermentable (SWI/SNF)...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA-Binding Proteins

Mutation

ErbB Receptors

Biomarkers, Tumor

Prognosis

Source

Identifiers

PMID: 40466463
DOI: 10.1016/j.lungcan.2025.108594

Genes

ARID1A
EGFR

Provenance

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