Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An antioxidant response element regulates the HIF1α axis in breast cancer cells.

Free radical biology & medicine - 1 Aug 2023

Lacher Sarah E, Skon-Hegg Cara, Ruis Brian L, Krznarich Jennifer, Slattery Matthew

Abstract excerpt

The redox sensitive transcription factor NRF2 is a central regulator of the transcriptional response to reactive oxygen species (ROS). NRF2 is widely recognized for its ROS-responsive upregulation of antioxidant genes that are essential for mitigating the damaging effects of oxidative stress. However, multiple genome-wide approaches have suggested that NRF2's regulatory reach extends well beyond the canonical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mutation

Share to NF-E2-Related Factor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 37179033
DOI: 10.1016/j.freeradbiomed.2023.05.003
PMCID: PMC10321210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An antioxidant response element regulates the HIF1α axis in breast cancer cells.PMID 37179033Read ↗

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.Semantic proximity Read ↗

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.Semantic proximity Read ↗

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations.Semantic proximity Read ↗

Ionizing Radiation Activates the Nrf2 Antioxidant ResponseSemantic proximity Read ↗

ERO1α as a potential drug target for breast cancer: a systematic review of current evidenceSemantic proximity Read ↗

NRF2 expression level and estrogen function in BRCA1-mutated breast cancer.Semantic proximity Read ↗

Functional polymorphisms in Nrf2: implications for human disease.Semantic proximity Read ↗

Nrf2, the master redox switch: the Achilles' heel of ovarian cancer?Semantic proximity Read ↗

BRCA1 induces antioxidant gene expression and resistance to oxidative stress.Semantic proximity Read ↗

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomesSemantic proximity Read ↗

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancerSemantic proximity Read ↗

FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.