Article
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.
The Journal of experimental medicine - 29 Jul 2013
Gorrini Chiara, Baniasadi Pegah S, Harris Isaac S, Silvester Jennifer, Inoue Satoshi, Snow Bryan, Joshi Purna A, Wakeham Andrew, Molyneux Sam D, Martin Bernard, Bouwman Peter, Cescon David W, Elia Andrew J, Winterton-Perks Zoe, Cruickshank Jennifer, Brenner Dirk, Tseng Alan, Musgrave Melinda, Berman Hal K, Khokha Rama, Jonkers Jos, Mak Tak W, Gauthier Mona L
Abstract excerpt
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-depen...
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