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Ionizing Radiation Activates the Nrf2 Antioxidant Response

13 Oct 2010

Abstract excerpt

The transcription factor NF-E2-related factor 2 (Nrf2) binds the antioxidant DNA response element (ARE) to activate important cellular cytoprotective defense systems. Recently several types of cancers have been shown to overexpress Nrf2, but its role in the cellular response to radiation therapy has yet to be fully determined. In this study, we report that single doses of ionizing radiation from 2 to 8 Gy...

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PMID: 20940400
DOI: 10.1158/0008-5472.can-10-0171

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