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Article

NRF2 expression level and estrogen function in BRCA1-mutated breast cancer.

BMC cancer - 21 Oct 2025

Derismahafi Zeinab, Farhud Dariush, Razavirad Amirhossein, Muhammadnejad Ahad, Jahanbin Behnaz, Farivar Shirin, Shirkoohi Reza

Abstract excerpt

BACKGROUND: Breast cancer (BC) is the most common malignancy diagnosed in women, with approximately 5–10% of cases attributed to hereditary factors. Although the tumor suppressor breast cancer susceptibility gene 1(BRCA1) is ubiquitously expressed, it is not clear why BRCA1 mutations overwhelmingly predispose to breast and ovarian cancers. Estrogen has been proposed to promote the survival of BRCA1-deficient...

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Source

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Identifiers

PMID: 41120975
DOI: 10.1186/s12885-025-14781-x
PMCID: PMC12542346

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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