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Article

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations.

Redox biology - 1 Oct 2018

Levings Daniel C, Wang Xuting, Kohlhase Derek, Bell Douglas A, Slattery Matthew

Abstract excerpt

NRF2 is a redox-responsive transcription factor that regulates expression of cytoprotective genes via its interaction with DNA sequences known as antioxidant response elements (AREs). NRF2 activity is induced by oxidative stress, but oxidative stress is not the only context in which NRF2 can be activated. Mutations that disrupt the interaction between NRF2 and KEAP1, an inhibitor of NRF2, lead to NRF2...

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Identifiers

PMID: 30195190
DOI: 10.1016/j.redox.2018.07.026
PMCID: PMC6128101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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