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Article

Nrf2, the master redox switch: the Achilles' heel of ovarian cancer?

Biochimica et biophysica acta - 1 Dec 2014

van der Wijst Monique G P, Brown Robert, Rots Marianne G

Abstract excerpt

Ovarian cancer is the most lethal gynecological tumor type in the world due to late stage detection, and resistance to chemotherapy. Therefore, alternative additional therapies are required. The etiology of ovarian cancer remains largely unknown, but risk factors point toward an important role for oxidative stress. Both healthy and tumor cells can cope with oxidative stress by activating the transcription factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25270772
DOI: 10.1016/j.bbcan.2014.09.004

Genes

BRAF
BRCA1
CUL3
ERBB2
KEAP1
KRAS
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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