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Article

Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease.

International journal of molecular sciences - 27 Apr 2023

Bryzgalov Leonid O, Korbolina Elena E, Merkulova Tatiana I

Abstract excerpt

Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling. Along with environmental factors, individual specific genetic features play a considerable...

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Identifiers

PMID: 37175659
DOI: 10.3390/ijms24097955
PMCID: PMC10177989

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