Article
Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy.
Ageing research reviews - 1 Sept 2013
Wang Jun, Yu Jin-Tai, Tan Meng-Shan, Jiang Teng, Tan Lan
Abstract excerpt
The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the interplay of environmental influences and individual genetic susceptibility. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, constitute dynamic intracellular processes for translating environmental stimuli into modifications in gene expression. Over the past decade it has become...
Topics
- Alzheimer Disease
- Animals
- DNA Methylation
- Drug Delivery Systems
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Genetic Therapy
- Humans
