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Epigenome-wide association studies in Alzheimer's disease; achievements and challenges.

Brain pathology (Zurich, Switzerland) - 1 Sept 2020

van den Hove Daniel L A, Riemens Renzo J M, Koulousakis Philippos, Pishva Ehsan

Abstract excerpt

Alzheimer's disease (AD) represents a devastating progressive neurodegenerative disease with a complex pathophysiology, affecting millions of people worldwide. Recent epigenome-wide association studies suggest a key role for epigenetic mechanisms in its development and course. Despite the fact that current evidence on the role of epigenetic dysregulation in aging and AD is convincing, the pioneering field of...

Topics

Age Factors
Alzheimer Disease
DNA Methylation
Epigenesis, Genetic
Epigenome
Epigenomics
Genetic Predisposition to Disease
Humans
Neurodegenerative Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32654262
DOI: 10.1111/bpa.12880
PMCID: PMC8018126

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