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Article

Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.

The EMBO journal - 15 Nov 2021

Robles-Valero Javier, Fernández-Nevado Lucía, Lorenzo-Martín L Francisco, Cuadrado Myriam, Fernández-Pisonero Isabel, Rodríguez-Fdez Sonia, Astorga-Simón Elsa N, Abad Antonio, Caloto Rubén, Bustelo Xosé R

Abstract excerpt

Mutations in VAV1, a gene that encodes a multifunctional protein important for lymphocytes, are found at different frequencies in peripheral T-cell lymphoma (PTCL), non-small cell lung cancer, and other tumors. However, their pathobiological significance remains unsettled. After cataloguing 51 cancer-associated VAV1 mutations, we show here that they can be classified in five subtypes according to functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34617326
DOI: 10.15252/embj.2021108125
PMCID: PMC8591544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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