Article
VAV1 mutations contribute to development of T-cell neoplasms in mice.
Blood - 24 Dec 2020
Fukumoto Kota, Sakata-Yanagimoto Mamiko, Fujisawa Manabu, Sakamoto Tatsuhiro, Miyoshi Hiroaki, Suehara Yasuhito, Nguyen Tran B, Suma Sakurako, Yanagimoto Shintaro, Shiraishi Yuichi, Chiba Kenichi, Bouska Alyssa, Kataoka Keisuke, Ogawa Seishi, Iqbal Javeed, Ohshima Koichi, Chiba Shigeru
Abstract excerpt
Activating mutations in the Vav guanine nucleotide exchange factor 1 (VAV1) gene are reported in various subtypes of mature T-cell neoplasms (TCNs). However, oncogenic activities associated with VAV1 mutations in TCNs remain unclear. To define them, we established transgenic mice expressing VAV1 mutants cloned from human TCNs. Although we observed no tumors in these mice for up to a year, tumors did develop in...
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