Article
The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration.
Experimental gerontology - 1 Jul 2023
Picca Anna, Guerra Flora, Calvani Riccardo, Coelho-Júnior Hélio José, Leeuwenburgh Christiaan, Bucci Cecilia, Marzetti Emanuele
Abstract excerpt
Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to endogenous and/or environmental stressors. The coordination of mtDNA replication and transcription regulates the pace of mitochondrial biogenesis to guarantee the minimum number of organelles per cell. mtDNA inheritance follows a maternal lineage, although...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.