Article
Mitochondrial DNA and disease.
The Journal of pathology - 1 Jan 2012
Greaves Laura C, Reeve Amy K, Taylor Robert W, Turnbull Doug M
Abstract excerpt
Mitochondrial DNA (mtDNA) defects are a relatively common cause of inherited disease and have been implicated in both ageing and cancer. MtDNA encodes essential subunits of the mitochondrial respiratory chain and defects result in impaired oxidative phosphorylation (OXPHOS). Similar OXPHOS defects have been shown to be present in a number of neurodegenerative conditions, including Parkinson's disease, as well as...
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