Mitochondrial DNA mutations in human degenerative diseases and aging.

doi:10.1016/0925-4439(95)00021-u

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Article

Mitochondrial DNA mutations in human degenerative diseases and aging.

Biochimica et biophysica acta - 24 May 1995

Wallace D C, Shoffner J M, Trounce I, Brown M D, Ballinger S W, Corral-Debrinski M, Horton T, Jun A S, Lott M T

Abstract excerpt

A wide variety of mitochondrial DNA (mtDNA) mutations have recently been identified in degenerative diseases of the brain, heart, skeletal muscle, kidney and endocrine system. Generally, individuals inheriting these mitochondrial diseases are relatively normal in early life, develop symptoms duri...

Topics

Adult
Aged
Aging
Amino Acid Sequence
Animals
Biological Evolution
Child
Conserved Sequence
DNA, Mitochondrial
Energy Metabolism
Female
Humans
Male
Middle Aged
Mitochondria
Mitochondrial Myopathies
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 7599200
DOI: 10.1016/0925-4439(95)00021-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7599200-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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