Article
Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.
EMBO molecular medicine - 1 Dec 2017
Mathivet Thomas, Bouleti Claire, Van Woensel Matthias, Stanchi Fabio, Verschuere Tina, Phng Li-Kun, Dejaegher Joost, Balcer Marly, Matsumoto Ken, Georgieva Petya B, Belmans Jochen, Sciot Raf, Stockmann Christian, Mazzone Massimiliano, De Vleeschouwer Steven, Gerhardt Holger
Abstract excerpt
Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tumor progression are poorly understood. Using longitudinal intravital imaging in a mouse glioma model, we identify that dynamic sprouting and functional morphogenesis...
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