Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1

11 May 2023

Abstract excerpt

BACKGROUND: ISGylation is a post-translational protein modification that regulates many life activities, including immunomodulation, antiviral responses, and embryo implantation. The exact contribution of ISGylation to folliculogenesis remains largely undefined. RESULTS: Here, Isg15 knockout in mice causes hyperfertility along with sensitive ovarian responses to gonadotropin, such as increases in cumulus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to interferon and immune responses
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37170317
DOI: 10.1186/s13578-023-01024-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1PMID 37170317Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

ISG15 and ISGylation in Human DiseasesSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signallingSemantic proximity Read ↗

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionSemantic proximity Read ↗

Post-Translational Modifications in Mammalian Folliculogenesis and Ovarian PathologiesSemantic proximity Read ↗

Emerging Roles for Immunomodulatory Functions of Free ISG15Semantic proximity Read ↗

ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial HomeostasisSemantic proximity Read ↗

ISG15: leading a double life as a secreted moleculeSemantic proximity Read ↗

Embryo Mortality in Isg15−/− Mice Is Exacerbated by Environmental Stress1Semantic proximity Read ↗

ISG15: A double edged sword in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.